Epidural clonidine applied as an adjunct to local anesthetics has a few unique mechanisms of action. First, the stimulation of alpha-2-receptors in the dorsal horn reduces agony transmission. Secondly, clonidine could cause regional vasoconstriction that limits vascular removing of area epidural anesthetics. For those who get dizzy when standing: https://socialimarketing.com/story5310619/detailed-notes-on-onolidine